2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124011
    m-PEG3-aldehyde 356066-46-1
    m-PEG3-aldehyde is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG3-aldehyde
  • HY-130653
    Azido-PEG4-C2-acid 1257063-35-6 ≥98.0%
    Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-C2-acid
  • HY-140214
    Azido-PEG5-amine 516493-93-9
    Azido-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-amine
  • HY-W008352
    Boc-NH-PEG4-CH2CH2NH2 811442-84-9 ≥98.0%
    Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG4-CH2CH2NH2
  • HY-130324
    Azido-PEG7-amine 1333154-77-0
    Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG7-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-amine
  • HY-W005056
    Boc-NH-PEG2-CH2COOH 108466-89-3 99.87%
    Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-CH2COOH
  • HY-140764
    Azido-PEG3-NHS ester 1092654-47-1 ≥98.0%
    Azido-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-NHS ester
  • HY-42490
    N3-PEG3-CH2CH2COOH 1056024-94-2 ≥98.0%
    N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2CH2COOH
  • HY-140941
    Biotin-PEG2-C2-iodoacetamide 292843-75-5 ≥98.0%
    Biotin-PEG2-C2-iodoacetamide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-C2-iodoacetamide
  • HY-140452
    Azido-PEG2-C2-acid 1312309-63-9
    Azido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C2-acid
  • HY-33615
    Methyl azetidine-3-carboxylate hydrochloride 100202-39-9 99.66%
    Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
    Methyl azetidine-3-carboxylate hydrochloride
  • HY-22340
    Azido-PEG4-alcohol 86770-67-4 98.64%
    Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG4-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-alcohol
  • HY-42149
    NH2-PEG2-C2-Boc 756525-95-8 ≥98.0%
    NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    NH2-PEG2-C2-Boc
  • HY-126887
    Mal-PEG8-NHS ester 2055033-05-9 98.44%
    Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG8-NHS ester
  • HY-43581
    endo-BCN-O-PNB 1263166-91-1 99.25%
    endo-BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-O-PNB
  • HY-140736
    DSPE-PEG-Biotin, MW 2000 385437-57-0
    DSPE-PEG-Biotin, MW 2000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-Biotin, MW 2000
  • HY-130291
    Biotin-PEG3-NHS ester 1253286-56-4 99.35%
    Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG3-NHS ester
  • HY-108368
    Azido-PEG2-CH2COOH 882518-90-3 99.03%
    Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-CH2COOH
  • HY-W015088
    Amino-PEG3-C2-Amine 929-75-9 99.32%
    Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-Amine
  • HY-135820
    m-PEG12-acid 2135793-73-4 99.12%
    m-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-acid
PROTAC Linkers Isoform Comparison

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